Giri lab focuses on deciphering the structure-function paradigm and structure-based drug discovery against viral systems such as flaviviruses and coronaviruses. For protein biophysical analysis, we employ different spectroscopic and microscopic techniques such as circular dichroism, fluorescence-based techniques, etc. We integrate computational and pharmacological approaches for further in-vitro investigations. 

Our work is sponsored by various prestigious grants from the Department of Science and Technology (DST) - Science and Engineering Research Board (SERB), Department of Biotechnology (DBT), and Indian Council of Medical Research (ICMR), Govt. of India.

Our recent published articles

Amyloidogenic proteins in the SARS-CoV and SARS-CoV-2 proteomes

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Intrinsic disorder in proteins associated with oxidative stress-induced JNK signaling

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Microsecond simulations and CD spectroscopy reveals the intrinsically disordered nature of SARS-CoV-2 spike-C-terminal cytoplasmic tail (residues 1242–1273) in isolation

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The signal peptide of the amyloid precursor protein forms amyloid-like aggregates and enhances Ab42 aggregation

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A novel inhibitor L755507 efficiently blocks c-Myc/MAX heterodimerization and induces apoptosis in cancer cells 

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Zika virus capsid anchor forms cytotoxic amyloid-like fibrils

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Small molecule inhibitors possibly targeting the rearrangement of Zika virus envelope protein

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